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Definition: A covalent bond between the sulfur atoms of two cysteine amino acids. Formation of such bonds between nonadjacent cysteines in a polypeptide stabilizes the tertiary structure of a protein; disulfide bonds between cysteines of different polypeptides contribute to the quaternary structure of a protein.
Source: Hickman, C.P., et al. 2011. Integrated Principles of Zoology. Fifteenth Edition. McGraw-Hill Higher Education.