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Post date: 11/19/2012
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Loss Of Heterozygosity

  • Definition: Loss of the presence of the wildtype allele, or loss of its function, in a heterozygous cell, enabling the phenotype of a recessive mutant allele to be expressed; mechanisms for loss of heterozygosity include chromosome loss, gene conversion, and mutation.

    Source: Essential Genetics: A genomics perspective (2006) 4th Ed.

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